Biofilm refers to a special structure formed when microorganisms adsorb on solid surfaces and secrete extracellular polymers (EPS) to wrap themselves in the solid surface in order to adapt to the living environment during their growth. It is composed of microbial cells and extracellular polymers (EPS). It has a complex three-dimensional structure with pores and channels. It protects microorganisms, improves their ability to obtain nutrients, and increases their drug resistance.

Locations where biofilms are easily formed

Biofilms are easily formed and cause serious harm in the pharmaceutical industry, food processing industry, dairy processing industry, and medical industry. According to the analysis of biofilm removal cases in the pharmaceutical industry by Fantong, biofilms are prone to occur in the following links and equipment facilities.

1. Water system equipment

Including pipes and storage tanks, filters of purified water systems and pipes, storage tanks and filters of injection water systems.

2. Fermentation tanks

Fermentation tanks are key equipment for microbial fermentation in pharmaceutical factories. During the fermentation process, the nutrients in the tank are rich, the temperature is suitable, and the humidity is high, which provides good conditions for the growth of microorganisms. Microorganisms are prone to form biofilms on the inner wall of the fermentation tank, agitators, temperature sensors and other parts.

3. Filling pipes and valves

Filling pipes and valves are in direct contact with drugs. If they are not cleaned thoroughly or disinfected strictly, microorganisms are easy to attach to their surfaces and form biofilms.

4. Filling pumps

The internal structure of the filling pump is complex, and it is easy to leave residual drugs and cleaning fluids, which provides conditions for the growth of microorganisms. Microorganisms form biofilms on the surface of the filling pump, which will affect the performance of the pump and the filling accuracy of the drugs.

5. Air conditioning and ventilation systems

The air conditioning and ventilation systems of pharmaceutical factories are used to maintain the cleanliness, temperature and humidity of the production environment. Dust and microorganisms are easily accumulated on the surface of air ducts and filters, and biofilms are formed under suitable conditions.

Biofilm contamination may cause interruptions in the pharmaceutical production process, resulting in reduced output or substandard product quality. This will not only affect the reputation of the company, but also pose a serious threat to the survival and development of the company.

Fantong Biofilm Removal Service

The formation of biofilms is a complex process. Removing biofilms requires comprehensive consideration of multiple factors and a strategy combining multiple methods. Fantong Biotechnology has developed VT-GHP biofilm removal technology based on the characteristics of biofilm formation in pharmaceutical factories. This technology combines physical and chemical methods to effectively destroy the cell structure and extracellular polymers of microorganisms, thereby killing microorganisms and removing biofilms without damaging equipment and facilities.

Of course, the best measure to prevent the occurrence of biofilms is prevention, such as optimizing fluid dynamics conditions during the design process, strengthening environmental sanitation management during daily production, and cleaning and disinfecting equipment and facilities such as tanks and pipelines.